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Paracetamol is available as 325- mg or 500- mg tablets, which may include calcium stearate or magnesium stearate, cellulose, docusate sodium and sodium benzoate or sodium lauryl sulfate, starch, hydroxypropyl methylcellulose, propylene glycol, sodium starch glycolate, polyethylene glycol and red # 40. 13– 15† grade: strong; evidence: low. The paracetamol treatment nomogram has been validated as an excellent predictor of risk but only for acute ingestions of imme - diate release paracetamol with a known time of ingestion. Ate release paracetamol, or within 4 hours of immediate release paracetamol overdoses greater than 30 g. Abstract: paracetamol / acetaminophen is one of the most popular and most commonly used analgesic and antipyretic drugs around the world, available without a prescription, both in mono- and multi- component prepa- rations. Acetaminophen ( apap - also known as paracetamol in many countries) is a non- opioid analgesic and antipyretic agent used to treat pain and fever. Paracetamol is used as an analgesic and antipyretic, in the treatment of a wide variety of arthritic and rheumatic conditions involving musculoskeletal pain and in other painful disorders such as headache, dysmenorrhoea, myalgia and neuralgia. Paracetamol is being recommended by guidelines as a first or second- line drug for acute pain and chronic pain, especially for patients with limited therapeutic options and for the elderly. Keywords: pain, musculoskeletal, cancer, headache, elderly, paracetamol, guidelines go to: 1. It is used as a single agent for mild to moderate pain and combined with an opioid analgesic for severe pain.